刘运亭

职称：教授，博士生导师

邮箱：ytliu@hebut.edu.cn

教育背景：

2014.09-2017.12，南开大学，博士

2011.09-2014.06，南开大学，硕士

2007.09-2011.06，山东农业大学，本科

工作履历：

2024.11至今，河北工业大学化工学院，教授

2019.12-2024.10，河北工业大学化工学院，副教授

2018.02-2019.11，河北工业大学化工学院，讲师

学术任职：

1. 食品研究与开发青年编委

2. Processes客座编辑

研究领域与承担项目：

研究领域：化学催化与生物催化、金属-酶集成催化剂的设计构建、手性药物中间体不对称合成等

基金和项目：

1. 国家自然科学基金面上项目，2024-2027，50万，主持

2. 国家自然科学基金青年项目，2019-2022，24万，主持

3. 国家重点研发计划合成生物学重点专项子课题，2023-2028，64万，主持

4. 国家重点研发计划绿色生物制造重点专项子课题，2021-2024，100万，主持

5. 河北省自然科学基金杰出青年基金项目，2023-2025，50万，主持

6. 河北省重点研发计划生物医药创新专项，2021-2024，50万，主持

7. 河北省自然科学基金青年基金项目，2019-2021，6万，主持

8. 河北省高等学校科学技术研究重点项目，2019-2021，5万，主持

奖励与荣誉：

概述：河北省杰出青年基金获得者、河北工业大学元光学者；近五年，以第一/通讯作者在Nat. Commun.、Angew. Chem. Int. Ed.、ACS Catal.等高水平期刊发表SCI学术论文30余篇；获中国食品工业协会科技创新个人奖、中国化工学会基础研究成果二等奖、中国生产力促进创新发展一等奖、天津市食品学会科技创新一等奖等。

代表性著作：

[1] Yunting Liu, Teng Ma, Zhongxu Guo, Liya Zhou, Guanhua Liu, Ying He, Li Ma, Jing Gao, Jing Bai, Frank Hollmann* & Yanjun Jiang*, Asymmetric α-benzylation of cyclic ketones enabled by concurrent chemical aldol condensation and biocatalytic reduction, Nat. Commun. 2024, 15, 71. (IF = 14.7)

[2] Weixi Kong, Chen Huang, Liya Zhou, Jing Gao, Li Ma, Yunting Liu,* and Yanjun Jiang*, Modularization of Immobilized Multienzyme Cascades for Continuous-Flow Enantioselective C- H Amination, Angew. Chem. Int. Ed. 2024, e202407778. (IF = 16.1)

[3] Weixi Kong, Yunting Liu*, Chen Huang, Liya Zhou, Jing Gao, Nicholas J. Turner, and Yanjun Jiang*, Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase, Angew. Chem. Int. Ed. 2022, e202202264. (IF = 16.1)

[4] Yunting Liu, Linping Li, Jianhua Xie,* Qilin Zhou, Divergent asymmetric total synthesis of mulinane diterpenoids. Angew. Chem. Int. Ed. 2017, 56, 12708. (IF = 16.1)

[5] Weixi Kong, Jiawang Zhang, Liya Zhou, Guanhua Liu, Ying He, Li Ma, Frank Hollmann, Lihui Wang, Yunting Liu,* and Yanjun Jiang*, Activation and Stabilization of Engineered Amine Dehydrogenase by Fatty Acids for Bioprocess Intensification of Asymmetric Reductive Amination, ACS Catal. 2025, 15, 34-43. (IF = 11.3)

[6] Zhongxu Guo, Weixi Kong, Liya Zhou, Ying He, Li Ma, Guanhua Liu, Yunting Liu,* and Yanjun Jiang*, Organic Molecular Cage-Mediated pH-Responsive Reversible Protein Self-Assembly with Multi-Enhanced Enzymatic Performance, ACS Catal. 2025, 15, 3955-3966. (IF = 11.3)

[7] Yuqing Zhang, Chen Huang, Weixi Kong, Liya Zhou, Jing Gao, Frank Hollmann, Yunting Liu,* and Yanjun Jiang*, A Chemoenzymatic Cascade for the Formal Enantioselective Hydroxylation and Amination of Benzylic C-H Bonds, ACS Catal. 2024, 14, 17405-17412. (IF = 11.3)

[8] Chen Huang, Yunting Liu,* Weixi Kong, Guanhua Liu, Liya Zhou, Ying He, Jing Gao, and Yanjun Jiang*, Continuous-Flow Chemoenzymatic Enantioselective Synthesis of Chiral α‑Mono- and Difluoromethyl Amines, ACS Catal. 2023, 13, 12960-12969. (IF = 11.3)

[9] Pengqian Luan, Yongxing Li, Chen Huang, Lele Dong, Teng Ma, Jianqiao Liu, Jing Gao, Yunting Liu*, and Yanjun Jiang*, Design of De Novo Three-Enzyme Nanoreactors for Stereodivergent Synthesis of α-Substituted Cyclohexanols, ACS Catal. 2022, 12, 7550. (IF = 11.3)

[10] Shiqi Gao, Yunting Liu*, Lihui Wang, Zihan Wang, Pengbo Liu, Jing Gao, and Yanjun Jiang*, Incorporation of Metals and Enzymes with Porous Imine Molecule Cages for Highly Efficient Semiheterogeneous Chemoenzymatic Catalysis. ACS Catal. 2021, 11, 5544. (IF = 11.3)

[11] Shiqi Gao, Zihan Wang, Li Ma, Yunting Liu*, Jing Gao*, and Yanjun Jiang*, Mesoporous Core-Shell Nanostructures Bridging Metal and Biocatalyst for Highly Efficient Cascade Reactions, ACS Catal. 2020, 10, 1375. (IF = 11.3)

[12] Shuling Zhang, Yuqing Zhang, Weixi Kong, Wanting Guo, Quan Yuan, Yanjun Jiang,* Yunting Liu,* Discovery, engineering, and applications of the ketoreductases from Metabacillus lacus in the synthesis of chiral (Hetero)aryl alcohols, Chem. Eng. J. 2025, 511, 161964. (IF = 13.3)

[13] Yunting Liu, Pengbo Liu, Shiqi Gao, Zihan Wang, Pengqian Luan, Javier Gonz´alez-Sabínc, Yanjun Jiang, Construction of Chemoenzymatic Cascade Reactions for Bridging Chemocatalysis and Biocatalysis: Principles, Strategies and Prospective, Chem. Eng. J. 2021, 420, 127659. (IF = 13.3)

[14] Mengmeng He, Xiaoyang Yue,* Jianqiao Liu, Guanhua Liu, Liya Zhou, Ying He, Li Ma, Yunting Liu*, Yanjun Jiang*, Engineered amine oxidase for efficient oxidative dehydroaromatization of 1,2,3,4-tetrahydroquinolines toward quinolines in aqueous media, Green Chem. 2025, 27, 4603-4610. (IF = 9.3)

[15] Yunting Liu, Jiajing Yan, Quan Yuan, Li Ma, Liya Zhou, Guanhua Liu, Xiaoyang Yue*, Yanjun Jiang*, Enzymatic reduction of halogenated aryl ketones in an aqueous micellar solution with enhanced catalytic performance, Green Chem. 2024, 26, 6666-6674. (IF = 9.3)

[16] Pengqian Luan, Yunting Liu,* Yongxing Li, Chen Huang, Jing Gao, Frank Hollmann, Yanjun Jiang*, Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation, Green Chem. 2021, 23, 1960-1964. (IF = 9.3)

专利申请与授权情况：

[1] 刘运亭、栾鹏仟、高静、姜艳军，三酶纳米反应器及其应用和手性叔α-苯基环醇的合成，专利号：ZL202210500883.7，授权日期：2024.01.05。

[2] 刘运亭、孔维茜、贺莹、姜艳军、高静，胺脱氢酶及其编码核酸与应用，专利号：ZL202210216532.3，授权日期：2023.09.15。

[3] 刘运亭、孔维茜、贺莹、姜艳军、高静，手性α-杂芳基胺及其制备方法，专利号：ZL202210217346.1，授权日期：2023.06.23。

[4] 刘运亭、高士耆、姜艳军、高静，半均相金属酶集成纳米催化剂，专利号：ZL202110309470.6，授权日期：2023.03.21。

[5] 刘运亭、栾鹏仟、姜艳军、高静，叔α-芳基环酮的制备方法，专利号：ZL202110190279.4，授权日期：2022.12.09。

[6] 刘运亭、王子涵、姜艳军、高静、高丽雅，两亲核壳结构纳米催化剂与集成催化剂及两者的制备和应用，专利号：ZL202110026409.0，授权日期：2022.11.04。

招生专业：081700化学工程与技术（博士、硕士）、085602化学工程领域、086001生物技术与工程领域